Ingredients of the vaccines in India declared as per fact sheet and undeclared
Covishield and Covaxin have NOT been given market use authorization clearance, but only Emergency Use Authorization aged 18 and above. Recently, EUA has been opened for children from 15-18 years of age, DCGI has approved Covaxin for 12-18 years of age.
- Fetal bovine serum (FBS) is harvested from bovine fetuses taken from pregnant cows during slaughter by means of a cardiac puncture without any form of anaesthesia mentioned on the ICMR website.
- Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific cell line originally derived from human embryonic kidney cells grown in tissue culture taken from a female foetus.
- Adenovirus ChAdOx1 nCoV-19 or AZD1222 is an active component of the Covishield / AstraZeneca (Covishield)-Oxford vaccines which carries the instructions to make the ‘Spike protein’ (the spikes on the surface of SARS viruses) which acts as a ‘vector’ or a ‘carrier’ for the SARS CoV2 spike protein gene sequence.
- Polysorbate – 80 carries other components in the vaccine through the blood-brain barrier that could be detrimental to neural development. Polysorbate 80 has been linked to Infertility.
- Aluminium Hydroxide Gel – is a KNOWN Neurotoxin
1. Fetal bovine serum (FBS)
Fetal bovine serum (FBS) is harvested from bovine fetuses taken from pregnant cows during slaughter by means of a cardiac puncture without any form of anaesthesia mentioned on the ICMR website on Page 9
2. Human embryonic kidney 293 cells
Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific cell line originally derived from human embryonic kidney cells grown in tissue culture taken from a female fetus.
Ingredients of Covishield
Total List of Ingredients in Covishield:
- Adenovirus Vector ChAdOx1
- L-Histidine hydrochloride monohydrate
- Magnesium chloride hexahydrate
- Polysorbate 80
- Sodium chloride
- Disodium edetate dihydrate (EDTA)
- Bacteriostatic Water
3. Adenovirus ChAdOx1 nCoV-19 or AZD1222 (Ingredients of Covishield ChAdOx1 nCoV-19)
The active component of the Covishield / AstraZeneca (Covishield)-Oxford vaccines is a modified Adenovirus vector carrying the genetic instructions for the SARS-CoV-2 spike protein. This new viral entity is patented under the name ChAdOx1 nCoV-19 or AZD1222.
Adenoviruses are a family of viruses similar to coronaviruses that commonly affect humans with presumably mild symptoms such as cold, fever, etc.
The genetic sequence that carries the instructions to make the ‘Spike protein’ (the spikes on the surface of SARS viruses) is spliced on to this particular adenovirus, which acts as a ‘vector’ or a ‘carrier’ for the SARS CoV2 spike protein gene sequence.
As opposed to the Pfizer and Moderna vaccines that use mRNA as the active component, this product uses the double stranded DNA of the SARS-CoV-2.
4. Polysorbate – 80 (Ingredients of Covishield)
Polysorbate 80 is a non-ionic surfactant and emulsifier often used in foods and cosmetics.
Polysorbate 80 is used in Vaccines as a stabilizer and an excipient. It keeps all the ingredients evenly distributed. Another action of Polysorbate 80 is that is helps carry other components in the vaccine through the blood-brain barrier.
Compounds that are in the vaccine that are potential neuro-toxins are written off as ‘safe’ because they are unable to cross the blood-brain barrier. But Polysorbate 80 enhances the permeability through the BBB. Vaccines commonly contain potent neurotoxic compounds like aluminium, mercury, as well as bacterial/viral antigens that could be detrimental to neural development. Especially when injected to infants.
Injected Polysorbate 80 metabolizes into chemicals that are much more toxic than the original chemical. Polysorbate 80 has been linked to Infertility.
In a study with Neonatal female rats, when they were injected ip (0.1 ml/rat) of polysorbate 80 at days 4-7 after birth, resulted in their accelerated maturation, caused changes to the vagina and womb lining, hormonal changes, ovary deformities and degenerative follicles . Injected polysorbate 80 has been identified as a potent trigger for anaphylaxis
A study published in the Annals of Allergy, Asthma and Immunology (December 2005) concluded that polysorbate 80 should be included in the test battery for allergy to medications such as corticosteroids, since it could be a cause of anaphylaxis of unknown etiology (15)(16).
Ingredients of Covaxin BBV152
SARS COV 2 antigen in Covaxin, Bharat Biotech: COVAXIN contains 6µg of whole-virion inactivated SARSCoV-2 antigen (Strain: NIV-2020-770)
In the case of all covid related vaccines, it is abundantly made clear on all their manufacturer’s official documents that the vaccines do not stop the spread of covid and there is still a chance of fully vaccinated persons contracting it. This fact alone puts the credibility of the vaccine in question.
Covaxin is an inactivated live vaccine, developed by Hyderabad-based Bharat Biotech International Ltd in association with the Indian Council of Medical Research (ICMR) and the National Institute of Virology (NIV). Covaxin is a whole virion Inactivate vero cell derived platform technology, developed with the inactive Sars-CoV-2 virions. Since the ‘inactive’ viral particle would not be elucidating an immune response, Adjuvants are added in order to trigger the immune response and produce antibodies.
Total List of Ingredients In Covaxin:
6µg of whole-virion inactivated SARSCoV-2 antigen (Strain: NIV-2020-770)
Aluminum hydroxide gel (250 µg)
TLR 7/8 agonist (imidazoquinolinone) 15 µg
2-phenoxyethanol 2.5 mg
Phosphate ® buffer saline up to 0.5 ml.
5. Aluminium Hydroxide Gel
Aluminium Hydroxide Gel – is a KNOWN Neurotoxin and is a commonly added as an adjuvant in Live, attenuated vaccines.
Imidazoquinolinone (Toll-Like Receptor 7 and 8 Agonists)
TLR 7/8 agonists have demonstrated potent adjuvant action, both in animal models and in humans. Studies generally demonstrate that TLR 7/8 agonists enhance Th1 responses and inhibit Th2 responses. In addition, CD8 T-cell responses can also be increased in some cases when using TLR 7/8 agonists as adjuvants. Despite these beneficial properties, the adjuvant effects seen with injectable imiquimod and resiquimod are at doses that also induce systemic cytokines, which potentially leads to side effects such as fever and flu-like symptoms.
6. Covaxin uses Beta-Propiolactone inactivation
The use of chemically inactivated pathogens is one of the most common vaccine strategies. It has a good track record of generating long-lasting immunity for many different viral diseases, such as flu, polio, and yellow fever. Nonetheless, this strategy is not universally suited to all viruses and can even have disastrous consequences if a molecular and structural understanding of the antigen is lacking. One such unfortunate example is the formalin-inactivated respiratory syncytial virus (FI-RSV) vaccine trial of the 1960s, which led to enhancement of disease symptoms in vaccinated children after natural exposure to RSV, with two fatal cases. The molecular mechanism of this negative effect of the RSV vaccine was not fully understood until the structures of formalin-inactivated RSV were determined (McLellan et al., 2013). The RSV spike is formed by the F protein, a class I fusion protein similar to coronaviruses’ S protein, and can adopt a prefusion or a postfusion state. Structural studies revealed that one contributing factor to the vaccine failure was that the prefusion state of the RSV spike was absent and the postfusion state was primarily represented in the FI-RSV vaccine formula (Killikelly et al., 2016; McLellan et al., 2013). This highlights the need to understand the differential roles of neutralizing and non-neutralizing antibodies elicited by vaccines and the challenge of avoiding antibody-dependent enhancement.
β-propiolactone is the chemical inactivating agent successfully used in rabies and other vaccines. Here we have shown that β-propiolactone-treated SARS-CoV-2 viruses exhibit most of their spikes in the postfusion conformation. It is possible that β-propiolactone could induce this conformation change, yet we cannot rule out the effect of purification and concentration procedures. Most COVID-19 vaccine candidates rely on the S protein as its antigen, since this is the primary exposed protein on the surface of the SARS-CoV-2 viral particle. As of July 7, 2020, 21 COVID-19 vaccine candidates were in clinical evaluation, 4 of them utilizing inactivated viruses (WHO, 2020a). β-propiolactone was used in three of four candidates as the inactivation reagent (Chen et al., 2020; Gao et al., 2020; Wrapp et al., 2020a; Xia et al., 2020) (Table S3). One of the vaccine candidates, PiCoVacc, was purified and inactivated the same way as in this study, and not surprisingly also showed substantial postfusion spikes, even though a prefusion state was incorrectly claimed (Gao et al., 2020). Therefore, structural studies, particularly on the conformational state of the viral spike in situ in intact virus particles, are paramount for these vaccine candidates, especially when the antigenicity of a vaccinal antigen is not predictive of the protective immunity elicited by it, as the FI-RSV trial shows.
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